Search results for "Giant-cell tumor of bone"

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Giant-cell tumor of bone, stage II, displaying translocation t(12;19)(q13;q13).

1989

A new case of giant-cell tumour (GCT) of bone with benign histological features, clinical stage II, has been reviewed with immunohistochemistry and electron microscopy. After short-term tissue culture the karyotype, using G-banding techniques, presented a consistent translocation t(12;19)(q13;q13). Nude mice xenografts of the tumour were unsuccessful after 6 months of follow-up. Presence of such chromosomal rearrangement may be related to locally aggressive, histologically benign giant-cell tumors of bone.

AdultPathologymedicine.medical_specialtyChromosomal translocationBone NeoplasmsChromosomal rearrangementStage iiBiologyTranslocation GeneticPathology and Forensic Medicinelaw.inventionTissue culturelawmedicineHumansMolecular BiologyNeoplasm StagingNeovascularization PathologicGiant Cell TumorsKaryotypeCell BiologyGeneral Medicinemedicine.diseaseImmunohistochemistryKaryotypingImmunohistochemistryFemaleElectron microscopeGiant-cell tumor of boneVirchows Archiv. A, Pathological anatomy and histopathology
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Denosumab in patients with resectable giant cell tumor of bone (GCTB): Effect on surgical downstaging in a "real world" experience

2015

e21505 Background: Pre- surgical treatment with denosumab has been associated with downstaging in patients (pts) with resectable GCTB. Here, we report our “real world” experience with pre-operative...

Cancer Researchmedicine.medical_specialtybusiness.industryGiant Cell Tumor; DenosumabGiant Cell Tumormedicine.diseaseSurgeryDenosumabOncologyMedicineIn patientDenosumabbusinessSurgical treatmentGiant-cell tumor of bonemedicine.drug
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